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Biomaterial Experimental Design
OVERVIEW
CEA CAPA Partner Institution: Universidad Carlos III de Madrid
Location: Madrid, Spain
Primary Subject Area: Biomedical Engineering
Instruction in: English
Transcript Source: Partner Institution
Course Details: Level 400
Recommended Semester Credits: 3
Contact Hours: 42
Prerequisites: Chemistry
Physics I
Cell and Molecular Biology
Biochemistry
Materials Science and Engineering
Anatomy and Physiology I and II
Introduction to Biomaterials
Fundamentals of Tissue Engineering and Regenerative Medicine
It is also recommended to have completed Biomechanics of continuum media I (solids) and Biomechanics of continuum media II (fluids)
DESCRIPTION
This course is designed to instruct the students in the experimental design of biomaterials for specific applications, including:
Fundamentals of biomaterials science and its application in biomedical engineering design. Selection and functionalization of biomaterials. Biocompatibility of materials. Designing biomaterials to control the transport of drugs and genes. Nanomedicine. Regulatory issues.
Biomaterials are substances that have been designed to direct the course of any therapeutic or diagnostic procedure by controlling interactions with biological systems. A large toolbox of non-biological materials has been engineered to study cell behavior at the cell-material interface. In this course, we will examine how this interface can be leveraged to study cellular systems and generate novel therapeutics. A critical evaluation of the primary research literature will be used to frame discussions about the interactions between cells and biomaterials. In particular, we will discuss how cell behavior can be altered by controlling biochemical and biophysical cues of substrate materials, how new organs and tissues can be produced by the use of structured scaffolds that direct cells into organized forms, and how specific patterning of materials can enable biological processes to be studied and altered at the single-cell level. We will also consider the applications at patterned cell-material interfaces to build artificial systems, such as organs-on-a-chip, which can be used to perform preclinical tests for the activity and toxicity of drug candidates. Also, we will discuss the combination of non-biological materials with genetic material (DNA and RNA), which can be a robust approach to modifying gene expression at the level of cells, tissues, or organs.
The course includes the following topics:
- Biomaterial selection for tissue engineering
- Nano and biomaterial design: microfabrication, modification and functionalization
- Biocompatibility of biomaterials: cell-material crosstalk
- Assessment of cell/protein-biomaterial interactions
- Nanotechnology and Targeted drug/protein/gene delivery systems
- Biomaterials for cell, tissue and organ on a chip:lab-on-a-chip devices
-Stem cell niche generation:high thorughput technologies
-3D-Bioprinting technology
- From lab to market: Regulatory issues
Fundamentals of biomaterials science and its application in biomedical engineering design. Selection and functionalization of biomaterials. Biocompatibility of materials. Designing biomaterials to control the transport of drugs and genes. Nanomedicine. Regulatory issues.
Biomaterials are substances that have been designed to direct the course of any therapeutic or diagnostic procedure by controlling interactions with biological systems. A large toolbox of non-biological materials has been engineered to study cell behavior at the cell-material interface. In this course, we will examine how this interface can be leveraged to study cellular systems and generate novel therapeutics. A critical evaluation of the primary research literature will be used to frame discussions about the interactions between cells and biomaterials. In particular, we will discuss how cell behavior can be altered by controlling biochemical and biophysical cues of substrate materials, how new organs and tissues can be produced by the use of structured scaffolds that direct cells into organized forms, and how specific patterning of materials can enable biological processes to be studied and altered at the single-cell level. We will also consider the applications at patterned cell-material interfaces to build artificial systems, such as organs-on-a-chip, which can be used to perform preclinical tests for the activity and toxicity of drug candidates. Also, we will discuss the combination of non-biological materials with genetic material (DNA and RNA), which can be a robust approach to modifying gene expression at the level of cells, tissues, or organs.
The course includes the following topics:
- Biomaterial selection for tissue engineering
- Nano and biomaterial design: microfabrication, modification and functionalization
- Biocompatibility of biomaterials: cell-material crosstalk
- Assessment of cell/protein-biomaterial interactions
- Nanotechnology and Targeted drug/protein/gene delivery systems
- Biomaterials for cell, tissue and organ on a chip:lab-on-a-chip devices
-Stem cell niche generation:high thorughput technologies
-3D-Bioprinting technology
- From lab to market: Regulatory issues
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